Description The name progeria means "early age". It is the most well-known form of the premature aging diseases that include Werner syndrome, Cockayne syndrome and Rothmund-Thomson syndrome. Although born looking healthy, infants with progeria quickly start to display many characteristics of accelerated aging at around months of age Gilbert, Demographics Progeria has a reported incidence of about 1 in million newborns.
Atherosclerosis Progeria is a disease that produces rapid aging, beginning in childhood. Causes Progeria is a rare condition that is remarkable because its symptoms strongly resemble normal human aging, but occur in young children.
Ninety percent of children with progeria have a mutation on the gene that encodes the protein lamin A. Progeria usually occurs without cause.
A study from the Netherlands has shown an incidence of 1 in 4 million births. Currently, there are between 35 and 45 known cases in the world.
Classical Hutchinson-Gilford Progeria Syndrome is almost never passed on from parent to child. It is usually caused by a new sporadic mutation during the early division of the cells in the child. It is usually genetically dominant; therefore, parents who are healthy will normally not pass it on to their children.
Affected children rarely live long enough to have children themselves. There have been only two known cases in which it became evident that a healthy parent can carry the LMNA mutation that causes progeria.
A family from India has five children with progeria; they were the subject of a Bodyshock documentary entitled The 80 Year Old Children. In the other case, a family from Belgium has two children with progeria. Symptoms of progeria include: Symptoms Growth failure during the first year of life Narrow, shrunken or wrinkled face BaldnessBaldness Loss of eyebrows and eyelashes Short statureshort stature Large head for size of face macrocephalymacrocephaly Open soft spot fontanelle Small Jaw micrognathiamicrognathia Dry, scaly, thin skin Limited range of motionLimited range of motion Teeth — delayed or absent formationTeeth — delayed or absent formation Some exams and tests that can be run to determine if a child is diagnosed with progeria include: Exams and Tests Insulin-resistant diabetesdiabetes diabetes that does not respond readily to insulin injections Skin changes similar to that seen in scleroderma the connective tissue becomes tough and hardened Cardiac stress testing may reveal signs ot early atherosclerosis of blood vessels.
Genetic testing can detect mutations in lamin A that cause progeria. Treatment Treatment There is presently no treatment for progeria. Several discoveries have been made that have led to greater understanding and perhaps eventual treatment.
A report in Nature said that progeria may be a de novo dominant trait. It develops during cell division in a newly conceived zygote or in the gametes of one of the parents. It is caused by mutations in the LMNA lamin A protein gene on chromosome 1; the mutated form of lamin A is commonly known as progerin.
Death occurs almost exclusively due to widespread heart disease, the leading cause of death in the US, and 2 worldwide. As with any person suffering from heart disease, the common events for Progeria children are strokes, high blood pressure, angina, enlarged heart, and heart failure, all conditions associated with aging.
In the general community, the prevalence of cardiovascular disease starts appearing in the 60s and 70s. Because finding a cure for Progeria will not only help these children, but may provide keys for treating millions of adults with heart disease and stroke associated with the natural aging process.
Because the aging process is ccelerated in children with Progeria, they offer researchers a rare opportunity to observe in Just a few years what would otherwise require decades of longitudinal studies.
A better understanding of the causes of this syndrome Progeria could lead to better insights into the mechanisms of both development and aging. Whelm Bohr, chairman of molecular gerontology at the National Institute on Aging Atherosclerosis Children with Progeria also develop and die of atherosclerosis and arteriosclerosis commonly referred to as heart disease.
Some hardening of the arteries often occurs when people grow older. Atherosclerosis involves deposits ot tatty substances in the inner lining ot an artery.
This buildup is called laque. Plaques can grow large enough to significantly reduce the flow of blood through an artery, or plaques become fragile and rupture to form clots that can block blood flow.
If the blockage occurs to an artery that feeds into the heart, it causes a heart attack.Progeria Essay Examples & Outline Are you in High School, College, Masters, Bachelors or Ph.D and need someone to help write your college research paper?
All you need is to ask for research paper help written by a specialist in your academic field. This Research Paper Hutchinson-Gilford Progeria Syndrome and other 64,+ term papers, college essay examples and free essays are available now on r-bridal.com Autor: review • November 4, • Research Paper • 1, Words (8 Pages) • 1, Views.4/4(1).
Apr 28, · Words: Length: 5 Pages Document Type: Essay Paper #: Progeria is a somewhat mysterious illness that affects children all around the globe. The rapid ageing of individuals that suffer with the condition has intrigued scientist and researchers for decades.
Because the disease is so rare, very little is known about the condition. Progeria Research Paper Essay Sample.
Never assume that a person with wrinkled skin is an old person without knowing the truth. In a rare disease called Hutchinson-Gilford Progeria Syndrome better known as Progeria was identified.
Progeria research paper pdf.
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